Epigenetic modifications in distinction: histone versus DNA methylation in ESCs.
نویسندگان
چکیده
In this issue of Cell Stem Cell, Karimi et al. (2011) show that DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) have distinct genomic targets in mouse ESCs. In particular, loss of H3K9me3 leads to derepression of select endogenous retroviruses and subsequent ectopic transcription of adjacent genes.
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ورودعنوان ژورنال:
- Cell stem cell
دوره 8 6 شماره
صفحات -
تاریخ انتشار 2011